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Postdoctoral Position : multiscale Fruit Modeling: integrating biophysical fruit growth with biochemical metabolisms in 10 fruits

Postdoctoral Position : multiscale Fruit Modeling: integrating biophysical fruit growth with biochemical metabolisms in 10 fruits




Metabolism is an obvious target for crop improvement, especially in fruits, and understanding the mechanisms linking it to crop phenotypes will help to focus breeding strategies. Modeling plays a more and more important role in dissecting complex traits, such as metabolism, into more simple and stable ones. For example, stoichiometric (Flux balance analysis) and enzyme-based kinetic models can capture a clear picture of subcellular metabolic fluxes. However, the phenotype of a given trait is often a result of complex networks working at different organization levels. For example, fruit size is a function of cell number and cell expansion, where the former is tightly related to cell division and the latter depends largely on the biophysical properties of water transport that cannot be predicted solely from metabolic reactions. Instead, process-based models can successfully simulate the biophysical processes for fruit growth, without detailed incorporation of metabolic process. Therefore, linking process based models to the genetic basis of metabolism could lead to powerful tools to manipulate fruit biomass and quality. The existence of an integrated, multi-scale model could offer a useful framework to interpret omics data, in relation to environmental factors, developmental stages and agricultural practices. The integration of cellular and molecular levels can help refine plant models, shedding light onto the complex interplay between different spatial and temporal scales in the emerging system response. In particular, the integration of an enzyme-based kinetic model into a process-based model would enable the identification of those enzymes and/or transporters having the strongest control over a trait of interest, thus opening the possibility to manipulate this trait. However, the integration of models operating at different levels of organisation and/or involving different concepts is still rather seldom.


The French National Research Agency (ANR) has funded an innovation project entitled "FRuit Integrative MOdelling for a Unified Selection System" (FRIMOUSS). This research project is conducted by a consortium of three research groups, including UR 1115 (INRA, Avignon), UMR 1287 (INRA, Bordeaux), and UMR 1332 (INRA, Bordeaux), with rich expertise in fruit metabolism (metabolomics and enzyme activities), fruit metabolism modeling, process-based modeling of fruit growth. In the frame of this project, UMR 1287 at INRA (French National Institute of Agronomic Research) Bordeaux is offering a position for a postdoctoral scientist, for a duration of 24 months.


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Printed from on 25/11/17 11:25:49 AM

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